What is Rheumatoid Factor (RF)?
Rheumatoid factor (RF) is an autoantibody present in the blood, primarily associated with rheumatoid arthritis (RA), an autoimmune condition characterized by chronic inflammation of the joints.
Role in Rheumatoid Arthritis
RF is produced by the immune system and targets the body's own tissues, leading to joint damage and inflammation. Approximately 70-80% of individuals with RA test positive for RF, making it a significant marker for the diagnosis and monitoring of the disease.
Testing and Significance
The RF test is a blood test that measures the level of rheumatoid factor in the bloodstream. A positive RF test indicates a higher likelihood of rheumatoid arthritis, but it is not definitive. Some individuals without RA may also have elevated RF levels, indicating a need for further evaluation.
Other Contexts
While RF is predominantly associated with rheumatoid arthritis, elevated levels can also be observed in other autoimmune diseases and infections. Monitoring RF levels helps rheumatologists assess disease activity and treatment response in patients with RA.
In summary, Rheumatoid Factor is crucial in understanding and managing rheumatoid arthritis, underlining its role in autoimmune diseases and chronic health conditions.