What is Androgen Deprivation Therapy?
Androgen Deprivation Therapy (ADT) is a medical treatment designed to reduce levels of androgens, which are male hormones like testosterone, in the body. It is primarily used in the management of prostate cancer, particularly in cases where the cancer is advanced, aggressive, or recurrent.
The rationale behind ADT is that androgens can stimulate the growth of prostate cancer cells. By lowering these hormone levels, ADT can help slow down or even shrink the cancer, thereby improving patient outcomes. ADT can be achieved through surgical castration, medications, or a combination of both approaches.
Medications used in ADT include LHRH (luteinizing hormone-releasing hormone) agonists and antagonists, anti-androgens, and androgen synthesis inhibitors. Treatment options vary based on the individual patient's health status, cancer stage, and treatment goals.
While ADT can be effective in managing prostate cancer, it may also lead to side effects such as decreased libido, erectile dysfunction, hot flashes, weight gain, and increased risk of osteoporosis. Therefore, it's essential for patients to discuss potential benefits and risks with their healthcare providers.